http://www.dreamstime.com/royalty-free-stock-photo-adult-woman-beautiful-face-isolated-white-skin-care-concept-image30401325The Science of iDDNA® and Anti-Aging

Aging is not an episodic process; rather, it is the consequence of cumulative damage occurring at the molecular, cellular and tissue levels. Attenuation of aging is entirely dependent on mitigating such molecular damage by augmenting protection and compensatory repair mechanisms, or slowing the degenerative processes.

 

“A genetic variant is said to have clinical validity if its impact on human health is well understood, so that detecting the variant supplies useful information about the patient’s health or predispositions to disease.”
Clin Interv Aging. 2006 Sep; 1(3): 201–203. Published online 2006 Sep. PMCID: PMC2695179

 

The polymorphic nature of aging indicates that any anti-aging strategy has to start with a better understanding of genes that affect tissue viability. If we are to widen the gap between chronological and biological age, we must better understand the role of the individual genetic make-up and gene-expression in aging and how topicals and dietary ingredients can interact in a positive way.

 

SKIN AGING EXPLAINED
HYDRATION

The ability of the skin to collect and retain moisture with the help of molecules that assist in binding water to the skin is a major contributor to a glowing skin. However, as one gets older the genes that control this process of moisture retention become less active, resulting in drying of skin and formation of wrinkles.

FREE RADICALS DAMAGE

The skin’s response to free radicals that roam all around our body causing wide-spread damage to the DNA is also crucial for the health of the skin. It is found that genes govern the skin’s defenses against the free radicals and the process of aging invariably weakens these defences.

SKIN REGENERATION

Rejuvenation of skin or production of new skin cells is a natural process that protects the skin from aging and its allied conditions. Unfortunately with aging, the skin’s ability to produce new cells slows down.

INFLAMMATION

Aging also results in inflammation of skin cells. The genes that control the process of inflammation become more active with age, resulting in wrinkles.

 

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iDDNA® represents the first GENETIC APPROACH TO ANTI-AGING PERSONALIZED SOLUTIONS.

Your genes provide the governing frame of reference, it is your lifestyle that dictates how those genes are expressed – turned on and off. As important as they are, genes are not fixed elements, but rather are actively engaged in our lives, designed to take their signals from everything that happens to us from the moment of conception. Though your DNA remains protected, its working copy RNA ventures out into the cell to do its work – frequently adjusting its directives based on day to day experience: shaped by your daily interactions with your environment (free radicals, ultraviolet rays, carcinogens, pollution …), nutrition and exercise.

 

 

DO YOU REALLY KNOW YOUR SKIN?

Genetic studies have proven that the genes we inherit from our parents play a significant role in shaping our skin texture and complexion.

The human genome project has generated a lot of data which has enabled genetic scientists to identify the hereditary traits in the genetic composition of an individual. Progressive strides in genetic studies have allowed us to peek into the complicated and enigmatic biochemical processes involved in aging.

 

 

THE INDIVIDUAL GENETIC SIGNATURE
  • Up to 60% of the skin aging variation between individuals can be attributed to genetic factors, while the remaining 40% is due to non-genetic factors
  • Individuals can be divided into genetic clusters defined by genotypic variables.
  • These genotypic variables are linked with polymorphisms in one or more genes associated with certain properties of the skin that contribute to a person’s perceived age.
  • Therefore, by using this classification, it is possible to characterize human skin care and anti-aging needs on the basis of an individual’s genetic signature, thus opening the door to personalized treatments addressed at specific populations.

 

THE SECRET OF ANTI-AGING IS IN OUR GENES

A recent study led by Dr. Alexa Kimball, Professor of Dermatology, Harvard Medical School/Massachusetts General Hospital, and other leading scientific and analytical research partners in the fields of systems biology, skin biology, and 3D imaging and hormone mapping, confirms that the secret of people who look younger than their actual age depends on a limited group of genes responsible for a range of key biochemical pathways, including those involved in cellular energy production, cell junction and adhesion processes, skin and moisture barrier formation, DNA repair and replication, and anti-oxidant production.

There are distinct gene expression “tipping points” that occur in each decade as we age:

  1. Decline in antioxidant response (20s)
  2. Decline in skin bioenergy (30s)
  3. Increase in cellular senescence (40s)
  4. Decline in skin barrier function (50s)
  5. Acceleration of all the above (60s)
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If professional skin care is still treating individuals as a homogeneous group, it’s time for your treatment to get personal if you really want the

best outcome.

 

The iDDNA® genetic panel targets:
  • WRINKLING (firmness and elasticity)
  • MOISTURIZATION (hyaluronic acid potential)
  • COLLAGEN BREAKDOWN (glycation)
  • FREE RADICALS DAMAGE (photo-aging)
  • SKIN REGENERATION
  • SKIN SENSITIVITY (inflammation)

 

 Your iDDNA® therapy precisely addresses:
  • COLLAGEN GENERATION, ELASTIN, EMILIN (microfibrils which sustains skin firmness), INFLAMMATION (it works against collagen synthesis)
  • MOISTURIZATION (hyaluronic acid inner production), INFLAMMATION (your skin will be losing more hyaluronic acid), SKIN BARRIER (it defends against the loss of moisture)
  • COLLAGEN BREAKDOWN (collagen cross-linking depending on sugars’ metabolism)
  • FREE RADICALS DAMAGE (oxidative stress), PHOTO-AGING, SUN-DAMAGE, HYPER-PIGMENTATION
  • SKIN REGENERATION, CELL RENEWAL, SKIN VASCULARIZATION, SKIN OXYGENATION
  • SKIN SENSITIVITY, SKIN INFLAMMATION

This is the most comprehensive and personalized approach to look better for your age, with long-lasting natural results. Now, you can replace anti-aging guesswork with genetically-designed cosmeceuticals and functional nutraceuticals, based on your DNA.

Learn how it works.

Contact us and find out how to win the battle against aging skin.