Aging is not an episodic process; rather, it is the consequence of cumulative damage occurring at the molecular, cellular and tissue levels. Attenuation of aging is entirely dependent on mitigating such molecular damage by augmenting protection and compensatory repair mechanisms, or slowing the degenerative processes.
“A genetic variant is said to have clinical validity if its impact on human health is well understood, so that detecting the variant supplies useful information about the patient’s health or predispositions to disease.”
Clin Interv Aging. 2006 Sep; 1(3): 201–203. Published online 2006 Sep. PMCID: PMC2695179
The polymorphic nature of aging indicates that any anti-aging strategy has to start with a better understanding of genes that affect tissue viability. If we are to widen the gap between chronological and biological age, we must better understand the role of the individual genetic make-up and gene-expression in aging and how topicals and dietary ingredients can interact in a positive way.
The ability of the skin to collect and retain moisture with the help of molecules that assist in binding water to the skin is a major contributor to a glowing skin. However, as one gets older the genes that control this process of moisture retention become less active, resulting in drying of skin and formation of wrinkles.
The skin’s response to free radicals that roam all around our body causing wide-spread damage to the DNA is also crucial for the health of the skin. It is found that genes govern the skin’s defenses against the free radicals and the process of aging invariably weakens these defences.
Rejuvenation of skin or production of new skin cells is a natural process that protects the skin from aging and its allied conditions. Unfortunately with aging, the skin’s ability to produce new cells slows down.
Aging also results in inflammation of skin cells. The genes that control the process of inflammation become more active with age, resulting in wrinkles.
Your genes provide the governing frame of reference, it is your lifestyle that dictates how those genes are expressed – turned on and off. As important as they are, genes are not fixed elements, but rather are actively engaged in our lives, designed to take their signals from everything that happens to us from the moment of conception. Though your DNA remains protected, its working copy RNA ventures out into the cell to do its work – frequently adjusting its directives based on day to day experience: shaped by your daily interactions with your environment (free radicals, ultraviolet rays, carcinogens, pollution …), nutrition and exercise.
Genetic studies have proven that the genes we inherit from our parents play a significant role in shaping our skin texture and complexion.
The human genome project has generated a lot of data which has enabled genetic scientists to identify the hereditary traits in the genetic composition of an individual. Progressive strides in genetic studies have allowed us to peek into the complicated and enigmatic biochemical processes involved in aging.
A recent study led by Dr. Alexa Kimball, Professor of Dermatology, Harvard Medical School/Massachusetts General Hospital, and other leading scientific and analytical research partners in the fields of systems biology, skin biology, and 3D imaging and hormone mapping, confirms that the secret of people who look younger than their actual age depends on a limited group of genes responsible for a range of key biochemical pathways, including those involved in cellular energy production, cell junction and adhesion processes, skin and moisture barrier formation, DNA repair and replication, and anti-oxidant production.
There are distinct gene expression “tipping points” that occur in each decade as we age:
If professional skin care is still treating individuals as a homogeneous group, it’s time for your treatment to get personal if you really want the
This is the most comprehensive and personalized approach to look better for your age, with long-lasting natural results. Now, you can replace anti-aging guesswork with genetically-designed cosmeceuticals and functional nutraceuticals, based on your DNA.
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